For the absolute location of the Midwest Region we used the capital of Iowa, which is Des Moines. The center of Des Moines is about the center of the Midwest Region. The absolute location of Des Moines is 41º36ºN/93º36ºW. The Midwest Region is Northwest of North Carolina and is 1,106 miles away from NC. There are 12 states in the Midwest Region. The largest state in the Midwest Region is Minnesota.